Physicochemical features and toxicity of some vitamin based ionic liquids

A three novel vitamin based ionic liquids, cholinium nicotinate, cholinium biotinate and cholinium ascorbate were synthesized and characterized. For the first time the acidity constant for biotin was determined. Physicochemical properties such as density, electrical conductivity and viscosity were measured and nature of interactions was discussed from the obtained experimental results. Also, toxicity study of these ionic liquids has been performed using human non-tumor cell line (normal fetal lung fibroblasts, MRC-5) and rat liver hepatoma cell line (H-4-II-E). Antibacterial activity was determined by disc diffusion method on Gram negative bacteria Pseudomonas aeruginosa and Escherichia coli as well on Gram positive bacteria Staphylococcus aureus and Listeria monocytogenes.