Shapley Additive Explanations of Indicator PCB-138 Distribution in Breast Milk

Izdanje: International Scientific Conference on Information Technology and Data Related Research

DOI: 10.15308/Sinteza-2020-35-40

Oblast: Artificial Intelligence Atlas

Stranice: 35-40

Apstrakt:
Breastfeeding provides numerous health benefits for newborns by meeting the infantsʼ nutritional needs and supporting associated immunological protection. Maternal milk is high in fat, and therefore, represents a very suitable media for the bioaccumulation of lipophilic pollutants such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs). This makes breast milk the primary source of the infant’s postnatal exposure to persistent toxic xenobiotics. In this study, we applied a novel SHapley Additive exPlanations (SHAP) method to investigate the key parameters that govern distribution of PCB-138, an indicator of non-dioxin congeners, in the mother’s milk. According to the accuracy metrics, the eXtreme Gradient Boosting regression was successfully employed, with relative error below 20% and high correlation coefficient (r=0.97), for finding the relationships between PCB-138 and other non-dioxin congeners, mother’s age, and number of births. According to the results, PCB-156, PCB-180, HCB, HCH and PCB-118 have the major, while PCB-28, PCB-52 and PCB-189 have the minor impact on PCB-138 distribution in breast milk. Similar behavior of contaminants, which belong to the both indicator congener group (−28, −52, −180) and toxicologically relevant PCBs (−118, −189), was recognized. The SHAP conclusions were only partially consistent with the results of correlation analysis suggesting that POPs exhibit non-linear dynamics and interrelations. Therefore, the current knowledge on contamination of complex biomatrices would benefit from further detailed analyses of pollutant intermittent relationships.
Ključne reči: human biomonitoring, persistent organic pollutants (POPs), organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), Shapley Additive exPlanations (SHAP).
Priložene datoteke:
  • 35-40 ( veličina: 1,3 MB, broj pregleda: 70 )

Preuzimanje citata:

BibTeX format
@article{article,
  author  = {A. Stojić, M. Matek Sarić and S. Herceg Romanić}, 
  title   = {Shapley Additive Explanations of Indicator PCB-138 Distribution in Breast Milk},
  journal = {International Scientific Conference on Information Technology and Data Related Research},
  year    = 2020,
  pages   = {35-40},
  doi     = {10.15308/Sinteza-2020-35-40}
}
RefWorks Tagged format
RT Conference Proceedings
A1 Andreja Stojić
A1 Marijana Matek Sarić
A1 Snježana Herceg Romanić
T1 Shapley Additive Explanations of Indicator PCB-138 Distribution in Breast Milk
AD Univerzitet Singidunum, Beograd, Beograd, Srbija
YR 2020
NO doi: 10.15308/Sinteza-2020-35-40
Unapred formatirani prikaz citata
A. Stojić, M. Matek Sarić and S. Herceg Romanić, Shapley Additive Explanations of Indicator PCB-138 Distribution in Breast Milk, Univerzitet Singidunum, Beograd, 2020, doi:10.15308/Sinteza-2020-35-40